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A brief review on features of falciparum malaria during pregnancy

Alexandre Manirakiza, Eugène Serdouma, Richard Norbert Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock Mbetid Degana, Gislain Géraud Banthas Bata, Jean Methode Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou
  • Eugène Serdouma
    University of Bangui, Bangui, Central African Republic
  • Richard Norbert Ngbalé
    University of Bangui, Bangui, Central African Republic
  • Sandrine Moussa
    Pasteur Institute of Bangui, Bangui, Central African Republic
  • Samuel Gondjé
    Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
  • Rock Mbetid Degana
    Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
  • Gislain Géraud Banthas Bata
    Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
  • Jean Methode Moyen
    Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic
  • Jean Delmont
    Center for Training and Research in Tropical Medicine and Health, Faculty of Medicine North, Marseille, France
  • Gérard Grésenguet
    University of Bangui, Bangui, Central African Republic
  • Abdoulaye Sepou
    University of Bangui, Bangui, Central African Republic

Abstract

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

Keywords

Malaria; Plasmodium falciparum; pregnancy

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Submitted: 2017-03-24 17:03:16
Published: 2017-12-31 00:00:00
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Copyright (c) 2017 Alexandre Manirakiza, Eugène Serdouma, Richard Norbert Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock Mbetid Degana, Gislain Géraud Banthas Bata, Jean Methode Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou

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