A retrospective analysis of two-month sputum smear non-conversion in new sputum smear positive tuberculosis patients in the Free State Province, South Africa

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Nanteza Gladys Kigozi *
Perpetual Chikobvu
James Christoffel Heunis
Sonja van der Merwe
(*) Corresponding Author:
Nanteza Gladys Kigozi | kigozign@ufs.ac.za

Abstract

Little is known about the drivers of twomonth sputum smear non-conversion in the South African context. Our study sought to determine these factors in new sputum smear positive tuberculosis (TB) patients in South Africa’s Free State Province. A retrospective record review was conducted for all TB patients on treatment between 2003 and 2009. Twomonth sputum smear non-conversion was defined by a positive sputum smear result. Data was subjected to univariate, bivariate and regression analyses. Generalized linear regression models were used to estimate the risk for two-month sputum smear non-conversion. Age, pre-treatment sputum smear grading, HIV status and TB disease classification influenced two-month sputum smear non-conversion. Significant associations were thus established between health systems, microbiological, clinical and demographic factors, and two-month sputum smear non-conversion. This study provides program managers with evidence to support the development of more tailored TB care.

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Article Details

Author Biographies

Nanteza Gladys Kigozi, Centre for Health Systems Research & Development, University of the Free State

Researcher

Perpetual Chikobvu, Department of Community Health, University of the Free State; Free State Department of Health, Bloemfontein

biostatistician

James Christoffel Heunis, Centre for Health Systems Research & Development, University of the Free State

Associate Professor

Sonja van der Merwe, Free State Department of Health, Bloemfontein

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