Sociodemographic, lifestyle and therapeutic predictors of 2-year survival in HIV-infected persons receiving antiretroviral therapy in Benin

Authors

  • Charles Sossa Jerome National Program for Fight against AIDS (PNLS); Regional Institute of Public Health, University of Abomey-Calavi http://orcid.org/0000-0001-5886-2875
  • Maurice Agonnoudé National School of Epidemiology and Public Health, University of Parakou
  • Ghislain Emmanuel Sopoh Regional Institute of Public Health, University of Abomey-Calavi
  • Ali Imorou Bah-Chabi National Program for Fight against AIDS (PNLS)
  • Amédée de Souza National Program for Fight against AIDS (PNLS)
  • Moussa Bachabi National Program for Fight against AIDS (PNLS)
  • Gratien Gbetowenonmon National Program for Fight against AIDS (PNLS)
  • Victoire Agueh Regional Institute of Public Health, University of Abomey-Calavi
  • Edgard-Marius Ouendo Regional Institute of Public Health, University of Abomey-Calavi
  • Laurent Ouédraogo Regional Institute of Public Health, University of Abomey-Calavi

DOI:

https://doi.org/10.4081/jphia.2017.651

Keywords:

HIV/AIDS, survival, antiretroviral therapy, predictors, Benin

Abstract

The benefits of antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection have been well described. The objective of this study was to identify the predictors of two-year survival in persons living with HIV/AIDS (PLWHA) in Benin. This retrospective transversal study included all patients from 46 HIV/AIDS therapy sites across Benin who started ART between July 1st, 2011 and June 30th, 2012. The independent variables were patients’ sociodemographic, clinical, biological and therapeutic characteristics and their ART regimen. The main dependent variable was the time of death. Data were collected from medical records, using documentary review. Cox proportional hazards regression models were used to investigate factors associated with survival. Among the 771 PLWHA participants of the study, 18 (2.3%) died within the two-year period. The estimated mortality of the 771 PLWHA was 3% at 24 months. Among the sociodemographic, lifestyle and therapeutic characteristics studied, the main predictor of two-year mortality was poor adherence [odds ratio = 4.15, 95% confidence interval (1.55- 11.28)]. This study confirms that improving the survival of PLWHA receiving ART requires enhanced adherence.
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Published

27-09-2017

How to Cite

Sossa Jerome, C., Agonnoudé, M., Sopoh, G. E., Bah-Chabi, A. I., de Souza, A., Bachabi, M., Gbetowenonmon, G., Agueh, V., Ouendo, E.-M., & Ouédraogo, L. (2017). Sociodemographic, lifestyle and therapeutic predictors of 2-year survival in HIV-infected persons receiving antiretroviral therapy in Benin. Journal of Public Health in Africa, 8(1). https://doi.org/10.4081/jphia.2017.651

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Section

Original Articles