A brief review on features of falciparum malaria during pregnancy

  • Alexandre Manirakiza | alexandre.manirakiza@pasteur-bangui.org Pasteur Institute of Bangui, Bangui, Central African Republic. http://orcid.org/0000-0002-1873-8527
  • Eugène Serdouma University of Bangui, Bangui, Central African Republic.
  • Richard Norbert Ngbalé University of Bangui, Bangui, Central African Republic.
  • Sandrine Moussa Pasteur Institute of Bangui, Bangui, Central African Republic.
  • Samuel Gondjé Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
  • Rock Mbetid Degana Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
  • Gislain Géraud Banthas Bata Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
  • Jean Methode Moyen Ministry of Public Health, Population and AIDS Control, Bangui, Central African Republic.
  • Jean Delmont Center for Training and Research in Tropical Medicine and Health, Faculty of Medicine North, Marseille, France.
  • Gérard Grésenguet University of Bangui, Bangui, Central African Republic.
  • Abdoulaye Sepou University of Bangui, Bangui, Central African Republic.

Abstract

Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum-infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa.

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Published
2017-12-31
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Issue
Section
Reviews
Keywords:
Malaria, Plasmodium falciparum, pregnancy
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How to Cite
Manirakiza, A., Serdouma, E., Ngbalé, R. N., Moussa, S., Gondjé, S., Mbetid Degana, R., Banthas Bata, G. G., Moyen, J. M., Delmont, J., Grésenguet, G., & Sepou, A. (2017). A brief review on features of falciparum malaria during pregnancy. Journal of Public Health in Africa, 8(2). https://doi.org/10.4081/jphia.2017.668