Decrease on malaria clinical cases from 2017 to 2019 in Franceville, Southeast Gabon, Central Africa
Accepted: 16 May 2022
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Background. In Gabon, malaria remains a major public health problem. All malaria cases with axillary temperature ≥ 37.5°C with a parasites density ≥ 1200/μL are serious cases and must be treated as a medical emergency. Thus, early diagnosis is essential for successful treatment. Because of the impact of malaria on the population, the surveillance of malaria infections in hospitals is urgently needed. The aim of this study was to to assess of clinical cases of malaria in a private health structure in Franceville between 2017 and 2019.
Methods. For that, we conducted a retrospective study using data on malaria cases recorded in a private medical analysis laboratory in Franceville, southeast Gabon. Malaria was diagnosed in this laboratory using a Rapid Diagnostic Test and confirmed by microscopic analysis.
Results. Analysis of 2518 patient forms revealed an increase in malaria prevalence in Franceville between 2017-2019. The global clinical cases was 26.1% (658/2015). Children under 5 years (44.0%) and patients aged 5-14 years (40.1%) were more affected than patients aged ≥15 years (18.8%, P=0.0001). Malaria infection was also significantly dependent on season and gender. We observed at least three Plasmodium species and the predominant Plasmodium species was P. falciparum 80.0%, followed by P. ovale (19.5%) and P. malariae (17.8%).
Conclusion. Our study showed that malaria remains a public health priority for the population of Franceville and that the prevalence of clinical cases of malaria at the laboratory decrease between 2017 and 2019. Our results highlight the need for strategies to control malaria in Franceville, adapted to epidemiological contexts and environmental constraint.
Boundenga, L. in Malaria (IntechOpen, 2019).
Mourou, J. R. et al. Malaria transmission in Libreville: results of a one year survey. Malaria journal 11, 40, doi:10.1186/1475-2875-11-40 (2012). DOI: https://doi.org/10.1186/1475-2875-11-40
WHO. World malaria report 2020: 20 years of global progress and challenges. (2020).
community awareness of malaria transmission and control. The
Bouyou-Akotet, M. K. et al. Evidence of decline of malaria in the general hospital of Libreville, Gabon from 2000 to 2008. Malaria journal 8, 300, 2009. DOI: https://doi.org/10.1186/1475-2875-8-300
Maghendji-Nzondo, S. et al. Prevalence of malaria, prevention measures, and main clinical features in febrile children admitted to the Franceville Regional Hospital, Gabon. Parasite (Paris, France) 23, 32, doi:10.1051/parasite/2016032 (2016). DOI: https://doi.org/10.1051/parasite/2016032
Gallup, J. L. & Sachs, J. D. The economic burden of malaria. The American journal of tropical medicine and hygiene 64, 85-96 (2001). DOI: https://doi.org/10.4269/ajtmh.2001.64.85
Touray, A. O., Mobegi, V. A., Wamunyokoli, F. & Herren, J. K. Diversity and Multiplicity of P. falciparum infections among asymptomatic school children in Mbita, Western Kenya. Scientific reports 10, 5924, doi:10.1038/s41598-020-62819-w (2020). DOI: https://doi.org/10.1038/s41598-020-62819-w
Lalremruata, A. et al. Species and genotype diversity of Plasmodium in malaria patients from Gabon analysed by next generation sequencing. Malaria journal 16, 398, doi:10.1186/s12936-017-2044-0 (2017). DOI: https://doi.org/10.1186/s12936-017-2044-0
Antinori, S., Galimberti, L., Milazzo, L. & Corbellino, M. Plasmodium knowlesi: the emerging zoonotic malaria parasite. Acta tropica 125, 191-201, doi:10.1016/j.actatropica.2012.10.008 (2013). DOI: https://doi.org/10.1016/j.actatropica.2012.10.008
Brazeau, N. F. et al. Plasmodium vivax Infections in Duffy-Negative Individuals in the Democratic Republic of the Congo. Am J Trop Med Hyg 99, 1128-1133, doi:10.4269/ajtmh.18-0277 (2018). DOI: https://doi.org/10.4269/ajtmh.18-0277
Kavunga-Membo, H. et al. Molecular identification of Plasmodium species in symptomatic children of Democratic Republic of Congo. Malaria journal 17, 334, doi:10.1186/s12936-018-2480-5 (2018). DOI: https://doi.org/10.1186/s12936-018-2480-5
WHO. African Region-World Health Organization. brief Report, 3 (2018).
Landier, J. et al. Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme. Lancet (London, England) 391, 1916-1926, doi:10.1016/s0140-6736(18)30792-x (2018). DOI: https://doi.org/10.1016/S0140-6736(18)30792-X
Lekana-Douki, J. B., Pontarollo, J., Zatra, R. & Toure-Ndouo, F. S. Malaria in Gabon: results of a clinical and laboratory study at the Chinese-Gabonese Friendship Hospital of Franceville. Sante (Montrouge, France) 21, 193-198, doi:10.1684/san.2011.0263 (2011). DOI: https://doi.org/10.1684/san.2011.0263
Mawili-Mboumba, D. P. et al. Increase in malaria prevalence and age of at risk population in different areas of Gabon. Malaria journal 12, 3, doi:10.1186/1475-2875-12-3 (2013). DOI: https://doi.org/10.1186/1475-2875-12-3
Biteghe-Bi-Essone, J. et al. Submicroscopic infection from uncomplicated Plasmodium falciparum malaria of Franceville, southeastern Gabon. International Journal of Advanced Research 2, 117-123 (2014).
Assele, V., Ndoh, G. E., Nkoghe, D. & Fandeur, T. No evidence of decline in malaria burden from 2006 to 2013 in a rural Province of Gabon: implications for public health policy. BMC public health 15, 81, doi:10.1186/s12889-015-1456-4 (2015). DOI: https://doi.org/10.1186/s12889-015-1456-4
Boumbanda Koyo, C. S. et al. High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon. Am J Trop Med Hyg 102, 121-129, doi:10.4269/ajtmh.19-0368 (2020). DOI: https://doi.org/10.4269/ajtmh.19-0368
Bouyou-Akotet, M. K. et al. Falciparum malaria as an emerging cause of fever in adults living in Gabon, Central Africa. BioMed research international 2014, 351281, doi:10.1155/2014/351281 (2014). DOI: https://doi.org/10.1155/2014/351281
Woldearegai, T. G. et al. Characterization of Plasmodium infections among inhabitants of rural areas in Gabon. Scientific reports 9, 9784, doi:10.1038/s41598-019-46194-9 (2019). DOI: https://doi.org/10.1038/s41598-019-46194-9
Zoleko Manego, R. et al. Description of Plasmodium falciparum infections in central Gabon demonstrating high parasite densities among symptomatic adolescents and adults. Malaria journal 18, 371, doi:10.1186/s12936-019-3002-9 (2019). DOI: https://doi.org/10.1186/s12936-019-3002-9
Groger, M. et al. Prospective Clinical Trial Assessing Species-Specific Efficacy of Artemether-Lumefantrine for the
Treatment of Plasmodium malariae, Plasmodium ovale, and Mixed Plasmodium Malaria in Gabon. Antimicrobial agents and chemotherapy 62, doi:10.1128/aac.01758-17 (2018). DOI: https://doi.org/10.1128/AAC.01758-17
Makanga, B. et al. Ape malaria transmission and potential for ape-to-human transfers in Africa. Proceedings of the National Academy of Sciences of the United States of America 113, 5329-5334, doi:10.1073/pnas.1603008113 (2016). DOI: https://doi.org/10.1073/pnas.1603008113
Mawili-Mboumba, D. P. et al. Submicroscopic Falciparum Malaria in Febrile Individuals in Urban and Rural Areas of
Gabon. Am J Trop Med Hyg 96, 815-818, doi:10.4269/.ajtmh.15-0231 (2017).
Maghendji-Nzondo, S. et al. Malaria in urban, semi-urban and rural areas of southern of Gabon: comparison of the Pfmdr 1 and Pfcrt genotypes from symptomatic children. Malaria journal 15, 420, doi:10.1186/s12936-016-1469-1 (2016). DOI: https://doi.org/10.1186/s12936-016-1469-1
Kamgaing, E. K., Itu, B. B. M., Ulrich, B., Jean, K. & Simon, A. Emergence of Severe Malaria in Children Over 5 Years in Libreville. Clinical Research in Pediatrics 1, 1-5 (2018).
Ceesay SJ, Bojang KA, Nwakanma D, et al. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop 2012;121:166-74. DOI: https://doi.org/10.1016/j.actatropica.2011.11.005
Ferede G, Worku A, Getaneh A, et al. Prevalence of malaria from blood smears examination: a seven-year retrospective study from metema hospital, northwest Ethiopia. Malar Res Treat 2013;2013:704730. DOI: https://doi.org/10.1155/2013/704730
29. Kunuanunua TS, Nsibu CN, Bodi JM, et al. Severe malaria in children: A descriptive report from Kinshasa, the Democratic Republic of Congo. J Trop Pediatr 2015;61:272-8. DOI: https://doi.org/10.1093/tropej/fmv029
Feleke DG, Gebretsadik D, Gebreweld A. Analysis of the trend of malaria prevalence in Ataye, North Shoa, Ethiopia between 2013 and 2017. Malaria J 2018;17:323. DOI: https://doi.org/10.1186/s12936-018-2474-3
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