Manifestations of adverse events post Sinovac vaccine immunization at Wirasakti Hospital, Kupang

Authors

  • Aries Hasan Basri Wirasakti Hospital Kupang, Kupang, East Nusa Tenggara; Faculty of Public Health, Nusa Cendana University, Kupang, East Nusa Tenggara
  • Anderias Umbu Roga Faculty of Public Health, Nusa Cendana University, Kupang, East Nusa Tenggara https://orcid.org/0000-0001-5521-3132
  • Muntasir Basri Faculty of Public Health, Nusa Cendana University, Kupang, East Nusa Tenggara
  • Idawati Tresno Faculty of Medicine, Nusa Cendana University, Kupang, East Nusa Tenggara
  • Mariana Ch. D. Lerik Faculty of Public Health, Nusa Cendana University, Kupang, East Nusa Tenggara

DOI:

https://doi.org/10.4081/jphia.2023.1963

Keywords:

AEFI, COVID 19, Sinovac, Wirasakti hospital, vaccination

Abstract

Background. Since it was first discovered, COVID-19 has spread worldwide and has been declared a pandemic by the World Health Organization. One of the various efforts made to prevent the spread of COVID-19 is the development of the COVID-19 vaccine. One of the vaccines developed and used by the Indonesian government is the Sinovac vaccine. However, like vaccines in general, there are always vaccine safety problems which are better known as adverse events following immunization (AEFI).
Objective. The purpose of this study is to determine the AEFI manifestations that occurred in Sinovac vaccination participants at Wirasakti Hospital, Kupang.
Methods. The sample included 51 people, who later became known as research subjects. The criteria for vaccine recipients and instructions for recording AEFI refer to the technical guidelines issued by the Ministry of Health, namely the Decree of the Director General of Disease Prevention and Control number HK.02.02/4/1/2021 regarding technical instructions for implementation of vaccination in the context of combating pandemic COVID-19.
Results. The results showed that out of 198 vaccination participants, 15 of them had AEFI and those who had AEFI were women. The AEFI manifestations that occur are dizziness, palpitations, shortness of breath, cramps in the hands, and trembling hands. All AEFI that occurred are non-serious in nature.
Conclusion. Sinovac vaccine is relatively safe to use because only a small proportion of respondents (29.4%) have AEFI.

Download data is not yet available.

References

Rothan HA, Byrareddy SN. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun J. 2020;109(102433):1–4. DOI: https://doi.org/10.1016/j.jaut.2020.102433

Ren L-L, Wang Y-M, Wu Z-Q, Xiang Z-C, Guo L, Xu T, et al. Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J (Engl). 2020;133(9):1015–24. DOI: https://doi.org/10.1097/CM9.0000000000000722

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan , China. Lancet. 2020;395(February 15):497–506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5

WHO. Naming the coronavirus disease (COVID-19) and the virus that causes it. 2020.

Kochhar S, Salmon DA. Planning for COVID-19 vaccines safety surveillance. Vaccine. 2020;38(July):6194–8. DOI: https://doi.org/10.1016/j.vaccine.2020.07.013

Worldometer. Covid live update. 2021.

Satgas Covid-19. Peta sebaran covid-19. 2021. DOI: https://doi.org/10.35580/lageografia.v19i3.18670

Prüβ BM. Current state of the first covid-19 vaccines. Vaccines. 2021;9(1):1–12. DOI: https://doi.org/10.3390/vaccines9010030

Koesnoe S. Teknis Pelaksanaan Vaksin Covid dan Antisipasi KIPI. SatGas Imunisasi Dewasa PB PAPDI PP Perhimpun Alergi Imunol Jakarta Perhimpun Dr Spes Penyakit Dalam Indones cab Bogor. 2021;

Jeon M, Oh CE, Lee J. Adverse Events Following Immunization Associated with Coronavirus Disease 2019 Vaccination Reported in the Mobile Vaccine Adverse Events Reporting System. 2021;36(March):1–8. DOI: https://doi.org/10.3346/jkms.2021.36.e114

Sastroasmoro S, Ismael S. Dasar-Dasar Metodologi Penelitian Klinis. III. Jakarta: CV. Agung Seto; 2008.

Centre for Infectious Disease Epidemiology and Research-NUS. COVID-19 Situation Report 419. Singapore; 2021.

Klein SL, Jedlicka A, Pekosz A. The Xs and Y of immune responses to viral vaccines. Lancet Infect Dis. 2010;10(5):338–49. DOI: https://doi.org/10.1016/S1473-3099(10)70049-9

Harris T, Nair J, Fediurek J, Deeks SL. Assessment of sex-specific differences in adverse events following immunization reporting in Ontario, 2012–15. Vaccine. 2017;35(19):2600–4. DOI: https://doi.org/10.1016/j.vaccine.2017.03.035

Cook IF. Sex differences in injection site reactions with human vaccines. 2016;(January).

Poland GA, Ovsyannikova IG, Jacobson RM. Adversomics: The emerging field of vaccine adverse event immunogenetics. Pediatr Infect Dis J. 2009;28(5):431–2. DOI: https://doi.org/10.1097/INF.0b013e3181a6a511

Cook IF. Sex differences in injection site reactions with human vaccines. Hum Vaccin. 2009;5(7):441–9. DOI: https://doi.org/10.4161/hv.8476

Cate T, Couch R, Parker D, Baxter B. Reactogenicity, immunogenicity, and antibody persistence in adults given inactivated influenza virus vaccines - 1978. Rev Infect Dis. 1983;5:737–47. DOI: https://doi.org/10.1093/clinids/5.4.737

Klein SL, Pekosz A. Sex-based biology and the rational design of influenza vaccination strategies. J Infect Dis. 2014;209(SUPPL. 3). DOI: https://doi.org/10.1093/infdis/jiu066

Engler R, Nelson M, Klote M, Al E. Half- vs full-dose trivalent in- activated influenza vaccine (2004–2005): age, dose, and sex effects on immune responses. . Arch Intern Med. 2008;168:2405–14. DOI: https://doi.org/10.1001/archinternmed.2008.513

Pinheiro I, Dejager L, Libert C. X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromo- some-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females. BioEssays. 2011;(33):791–802. DOI: https://doi.org/10.1002/bies.201100047

Stamova B, Tian Y, Jickling G, Al E. The X-chromosome has a different pattern of gene expression in women compared with men with ischemic stroke. Stroke. 2012;43:326–34. DOI: https://doi.org/10.1161/STROKEAHA.111.629337

Gordeeva L, Shabaldin A, Semenova E, Glushkov A. Influence of genetic and phenotypical factors on the efficiency of the vaccination of young children against diphtheria and measles. Zh Mikrobiol Epidemiol Immunobiol. 2006;2:42–6.

Whitacre CC. Sex differences in autoimmune disease. Nat Immunol. 2001;2(9):777–80. DOI: https://doi.org/10.1038/ni0901-777

Chang W-H. A review of vaccine effects on women in light of the COVID-19 pandemic. Taiwan J Obstet Gynecol. 2020;59(January):812–20. DOI: https://doi.org/10.1016/j.tjog.2020.09.006

Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev | Immunol. 2016;16:626–38. DOI: https://doi.org/10.1038/nri.2016.90

Fink AL, Klein SL. The evolution of greater humoral immunity in females than males : implications for vaccine efficacy. Curr Opin Psychol. 2018;6(Mach 29):16–20. DOI: https://doi.org/10.1016/j.cophys.2018.03.010

Fischinger S, Boudreau CM, Butler AL, Streeck H, Alter G. Sex differences in vaccine-induced humoral immunity. Semin Immunopathol. 2019;41(December 13):239–49. DOI: https://doi.org/10.1007/s00281-018-0726-5

Klein SL, Marriot I, Fish EN. Sex-based differences in immune function and responses to vaccination. Trans R Soc Trop Med Hyg hypersensitivity. 2015;109:9–15. DOI: https://doi.org/10.1093/trstmh/tru167

Ontario PH. Weekly Summary Adverse Events Following Immunization ( AEFIs ) for COVID-19 in Ontario : December 13 , 2020 to March 6 , AEFI Report Characteristics. 2021;1–14.

McCartney PR. Sex-Based Vaccine Response in the Context of COVID-19. JOGNN - J Obstet Gynecol Neonatal Nurs. 2020;49(5):405–8. DOI: https://doi.org/10.1016/j.jogn.2020.08.001

Downloads

Published

19-04-2023

How to Cite

Basri, A. H., Umbu Roga, A., Basri, M., Tresno, I., & Lerik, M. C. D. (2023). Manifestations of adverse events post Sinovac vaccine immunization at Wirasakti Hospital, Kupang. Journal of Public Health in Africa, 14(4). https://doi.org/10.4081/jphia.2023.1963

Issue

Section

Original Articles