Eurycoma longifolia: an overview on the pharmacological properties for the treatment of common cancer
https://doi.org/10.4081/jphia.2023.2495
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Eurycoma longifolia plant, the so called Tongkat Ali in Malaysia, is a well grown prominent tree in all Southeast Asia. It is well known among traditional medicine practitioners as a curative plant for many diseases and health conditions. The major quassinoid from the plant is eurycomanone, which exhibits many prominent effects on various cancer cell lines. Numerous studies have shown that eurycomanone inhibits cancerous cell growth and encourages cell death both in vitro and in vivo test. Even though analyses of safety and toxicity have been conducted, there is still a substantial knowledge barrier when it comes to providing a scientific foundation for the molecular mechanism as well as intervention strategy in the living people cancer cell. In a way to offer adequate baseline data for future investigations based on molecular mechanism and intervention, the present work seeks to review the researches conducted to date on this herbal plant.
Refe Bodeker G, Ong CK. WHO Global Atlas of Traditional, Complementary and Alternative Medicine; World Health Organization: Geneva, Switzerland, 2005; Volume 1.
WHO. Traditional Medicine Strategy 2002–2005; World Health Organization: Geneva, Switzerland, 2002.
Duraz AY, Khan, SA. Knowledge, attitudes and awareness of community pharmacists towards the use of herbal medicines in muscat region. Oman Med. J. 2011, 26. DOI: https://doi.org/10.5001/omj.2011.115
Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin 2017;67:7-30. DOI: https://doi.org/10.3322/caac.21387
Keng H. Orders and Families of Malayan Seed Plants. Singapore University Press; Kent Ridge, Singapore: 1978.
Keng H., Keng R.S.L. The Concise Flora of Singapore: GYMNOSPERMS and Dicotyledons. Singapore University Press; Kent Ridge, Singapore: 1990.
Goh S.H., Chuah C., Mok J., Soepadmo E. Malaysian Medicinal Plants for the Treatment of Cardiovascular Diseases. Pelanduk Publications; Petaling Jaya, Malaysia: 1995.
Shaheed Ur Rehman, Kevin Choe, and Hye Hyun Yoo Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology, Molecules. 2016 Mar; 21(3): 331.
Christapher, Parayil Varghese & Ambrose, C. & Jin, S.C. & Lim, Y.J. & Keisaban, T.. (2013). Antioxidant and Anti-inflammatory Activity of Eurycoma Longifolia Jack, A Traditional Medicinal Plant in Malaysia. Int J Pharm Sci Nanotech. 5. 1875-1878. 10.37285/ijpsn.2012.5.4.7. DOI: https://doi.org/10.37285/ijpsn.2012.5.4.7
Kuo, P.C.; Damu, A.G.; Lee, K.H.; Wu, T.S. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Biorg. Med. Chem. 2004, 12, 537–544.
Tong KL, Chan KL, AbuBakar S, Low BS, Ma HQ, Wong PF. The in vitro and in vivo anti-cancer activities of a standardized quassinoids composition from Eurycoma longifolia on LNCaP human prostate cancer cells. PLoS One. 2015;10(3):e0121752. Epub 2015/04/01 DOI: https://doi.org/10.1371/journal.pone.0121752
Kuo P.C., Damu A.G., Lee K.H., Wu T.S. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Biorg. Med. Chem. 2004;12:537–544. doi: 10.1016/j.bmc.2003.11.017. DOI: https://doi.org/10.1016/j.bmc.2003.11.017
Darise M., Kohda H., Mizutani K., Tanaka O. Eurycomanone and eurycomanol, quassinoids from the roots of Eurycoma longifolia. Phytochemistry. 1982;21:2091–2093. doi: 10.1016/0031-9422(82)83050-1. DOI: https://doi.org/10.1016/0031-9422(82)83050-1
Tran T.V.A., Malainer C., Schwaiger S., Atanasov A.G., Heiss E.H., Dirsch V.M., Stuppner H. NF-κB Inhibitors from Eurycoma longifolia. J. Nat. Prod. 2014;77:483–488. doi: 10.1021/np400701k. DOI: https://doi.org/10.1021/np400701k
Park S., Nhiem N.X., Van Kiem P., Van Minh C., Tai B.H., Kim N., Yoo H.H., Song J.H., Ko H.J., Kim S.H. Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. Bioorg. Med. Chem. Lett. 2014;24:3835–3840. doi: 10.1016/j.bmcl.2014.06.058
Food and Drug Administration Guidance for Industry, Estimating the Maximum Safe Starting Dose in Initial Critical Trials for Therapeutics in Adult Healthy Volunteers. [(accessed on 3 March 2016)]; Available online: http://www.fda.gov/downloads/Drugs/.../Guidances/UCM078932.pdf
Chan K., Lee S., Sam T., Tan S., Noguchi H., Sankawa U. 13β,18-dihydroeurycomanol, a quassinoid from Eurycoma longifolia. Phytochemistry. 1991;30:3138–3141. doi: 10.1016/S0031-9422(00)98272-4. DOI: https://doi.org/10.1016/S0031-9422(00)98272-4
Miyake K., Tezuka Y., Awale S., Li F., Kadota S. Quassinoids from Eurycoma longifolia. J. Nat. Prod. 2009;72:2135–2140. doi: 10.1021/np900486f. DOI: https://doi.org/10.1021/np900486f
Itokawa H., Qin X.-R., Morita H., Takeya K. C18 and C19 quassinoids from Eurycoma longifolia. J. Nat. Prod. 1993;56:1766–1771. doi: 10.1021/np50100a016. DOI: https://doi.org/10.1021/np50100a016
Ang H.H., Hitotsuyanagi Y., Takeya K. Eurycolactones A–C, novel quassinoids from Eurycoma longifolia. Tetrahedron Lett. 2000;41:6849–6853. doi: 10.1016/S0040-4039(00)01159-X. DOI: https://doi.org/10.1016/S0040-4039(00)01159-X
Low B.S., Teh C.H., Yuen K.H., Chan K.L. Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat. Prod. Commun. 2011;6:337–341.
Gerber B, Scholz C, Reimer T, Briese V, Janni W. Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review. Breast Cancer Research and Treatment. 2006;95(3):199–209. DOI: https://doi.org/10.1007/s10549-005-9005-y
Low BS, Choi SB, Abdul Wahab H, Kumar Das P, Chan KL (2013) Eurycomanone, the major quassinoid in Eurycoma longifolia root extract increases spermatogenesis by inhibiting the activity of phosphodiesterase and aromatase in steroidogenesis. J Ethnopharmacol 149: 201–207. DOI: https://doi.org/10.1016/j.jep.2013.06.023
Low BS, Teh CH, Yuen KH, Chan KL (2011) Physico-chemical effects of the major quassinoids in a standardized Eurycoma longifolia extract (Fr 2) on the bioavailability and pharmacokinetic properties, and their implications for oral antimalarial activity. Nat Prod Commun 6: 337–341. DOI: https://doi.org/10.1177/1934578X1100600307
WHO. WHO Monographs on Selected Medicinal Plants, Vol. 2. 2020. Geneva, Switzerland: World Health Organization.
Rehman, S. U., Choe, K., & Yoo, H. H. (2016). Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology. Molecules (Basel, Switzerland), 21(3), 331. https://doi.org/10.3390/molecules21030331 DOI: https://doi.org/10.3390/molecules21030331
Solomon M., Erasmus N., Henkel R. In vivo effects of Eurycoma longifolia Jack (Tongkat Ali) extract on reproductive functions in the rat. Andrologia. 2014;46:339–348. doi: 10.1111/and.12082. DOI: https://doi.org/10.1111/and.12082
Omar Saeed Ali Al-Salahi ,Dan Ji ,Amin Malik Shah Abdul Majid,Chan Kit-Lam,Wan Zaidah Abdullah,Abdelhamid Zaki,Shah Kamal Khan Jamal Din,Narazah Mohd Yusoff ,Aman Shah Abdul Majid , Anti-Tumor Activity of Eurycoma longifolia Root Extracts against K-562 Cell Line: In Vitro and In Vivo Study, Published: January 7, 2014,https://doi.org/10.1371/journal.pone.0083818 DOI: https://doi.org/10.1371/journal.pone.0083818
Somayeh Fani, Behnam Kamalidehghan, Kong Mun Lo, Najihah Mohd Hashim, Kit May Chow, Fatemeh Ahmadipour, Synthesis, structural characterization, and anticancer activity of a monobenzyltin compound against MCF-7 breast cancer cells, Drug Des Devel Ther 2015 Nov 23;9:6191-201. doi: 10.2147/DDDT.S87064. DOI: https://doi.org/10.2147/DDDT.S87064
Fani S, Dehghan F, Karimian H, Mun Lo K, Ebrahimi Nigjeh S, Swee Keong Y, Soori R, May Chow K, Kamalidehghan B, Mohd Ali H, Mohd Hashim N., Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells via the Wnt/β-Catenin Signaling Pathway. PLoS One. 2016 Aug 16;11(8):e0160836. doi: 10.1371/journal.pone.0160836 DOI: https://doi.org/10.1371/journal.pone.0160836
Wong, Pooi-Fong & Cheong, Wei-Fun & Shu, Meng-Hooi & Teh, Chin-Hoe & Chan, Kit & Abu Bakar, Sazaly. (2011). Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Phytomedicine : international journal of phytotherapy and phytopharmacology. 19. 138-44. 10.1016/j.phymed.2011.07.001.
Satayavivad J., Noppamas S., Aimon S., Yodhathai T. Toxicological and antimalaria activity of Eurycoma longifolia Jack extracts in mice. Thai J. Phytopharm. 1998;5:14–27.
Singh S, Upadhyay AU, Ajay AK, Bhat MK. p53 regulates ERK activation in carboplatin induced apoptosis in cervical carcinoma: A novel target of p53 in apoptosis. FEBS Lett 581: 289-295, 2007 DOI: https://doi.org/10.1016/j.febslet.2006.12.035
Yusmazura Zakaria 1, Asmah Rahmat, Azimahtol Hawariah Lope Pihie, Noor Rain Abdullah, Peter J Houghton, Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53, Cancer Cell Int 2009 Jun 10;9:16 doi: 10.1186/1475-2867-9-16.
Yusmazura Zakaria, Asmah Rahmat, Azimahtol Hawariah Lope Pihie, Noor Rain Abdullah, and Peter J Houghton, Eurycomanone induce apoptosis in HepG2 cells via up-regulation of p53, Cancer Cell Int. 2009; 9: 16. Published online 2009 Jun 10. doi: 10.1186/1475-2867-9-16 DOI: https://doi.org/10.1186/1475-2867-9-16
Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene. 2006;25:3787–3800. DOI: https://doi.org/10.1038/sj.onc.1209556
Hishikawa K, Oemar BS, Tanner FC, Nakaki T, Luscher TF, Fujii T. Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7. J Biol Chem. 1999;274:37461–37466. DOI: https://doi.org/10.1074/jbc.274.52.37461
Cheah, S. C., and Azimahtol, H. L. P. 2004. Eurycomanone exert antiproliferative activity via apoptosis upon MCF-7 cells. Prosiding symposium Biologi Kebangsaan Malaysia ke-7. 73-77.
Chou T, Martin N. CompuSyn for drug combinations: PC software and user’s guide: a computer program for quantitation of synergism and antagonism in drug combinations, and the determination of IC50 and ED50 and LD50 values. ComboSyn, Paramus, NJ. 2005.
Choudhary Y.K., Bommu P., Ming Y.K., Zulkawi N.B. Acute, sub-acute, and subchronic 90-days toxicity of Eurycoma longifolia aqueous extract (Physta) in wistar rats. Int. J. Pharm. Pharm. Sci. 2012;4:232–238.
Kajahmohideen, Nur Haseena and Siti NurSyafiqah, Razi and Faisal, Ghasak Ghazi and Ashour, Abdelkader Elbadawy Abbas (2020) Cytotoxic activity of eurycoma longifolia jack against nasopharyngeal carcinoma cell lines. In: 9th Dental Students' Scientific Conference 2020, 24th February 2020, Kuantan, Pahang
Nurkhasanah Mahfudh and Azimahtol Hawariah Lope Pihie, Eurycomanone Induces Apoptosis through the UpRegulation of p53 in Human Cervical Carcinoma Cells, Journal of Cancer Molecules 4(4): 109-115, 2008.
Thu HE, Hussain Z, Mohamed IN, Shuid AN. Eurycoma longifolia, A Potential Phytomedicine for the Treatment of Cancer: Evidence of p53-mediated Apoptosis in Cancerous Cells. Curr Drug Targets. 2018;19(10):1109-1126. doi: 10.2174/1389450118666170718151913 DOI: https://doi.org/10.2174/1389450118666170718151913
Pooi-Fong Wong 1, Wei-Fun Cheong, Meng-Hooi Shu, Chin-Hoe Teh, Kit-Lam Chan, Sazaly AbuBakar, Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28, Phytomedicine, 2012 Jan 15;19(2):138-44. doi: 10.1016/j.phymed.2011.07.001 DOI: https://doi.org/10.1016/j.phymed.2011.07.001
Bhasin S., Cunningham G.R., Hayes F.J., Matsumoto A.M., Snyder P.J., Swerdloff R.S., Montori V.M. Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2010;95:2536–2559. doi: 10.1210/jc.2009-2354. DOI: https://doi.org/10.1210/jc.2009-2354
Li C.H., Liao J.W., Liao P.L., Huang W.K., Tse L.S., Lin C.H., Kang J.J., Cheng Y.W. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack) Evid. Based Complement. Altern. Med. 2013;2013 doi: 10.1155/2013/102987. DOI: https://doi.org/10.1155/2013/102987
Park, S.; Nhiem, N.X.; Van Kiem, P.; Van Minh, C.; Tai, B.H.; Kim, N.; Yoo, H.H.; Song, J.H.; Ko, H.J.; Kim, S.H. Five new quassinoids and cytotoxic constituents from the roots of Eurycoma longifolia. Bioorg. Med. Chem. Lett. 2014, 24, 3835–3840 DOI: https://doi.org/10.1016/j.bmcl.2014.06.058
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