Antiosteoarthritis activities of 70% ethanol extract of Eleutherine bulbosa (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis

Published: 16 March 2023
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  • Riza Ambar Sari Master Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Fina Luthfiana Master Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Irawati Sholihah Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Katsuyoshi Matsunami Department of Pharmacognosy, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
  • Sukardiman Sukardiman Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; Natural Products Drug Discovery and Development, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
  • Retno Widyowati Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya; Natural Products Drug Discovery and Development, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

Background: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, Eleutherine bulbosa bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory.

Objective: In this research, we employed an in vivo model to examine the effects of 70% ethanol extracts of E. bulbosa (EBE) on the progression and development of OA.

Methods: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia.

Results: Induction was successful, indicated by a significant difference (P<0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P<0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia.

Conclusion: The 70% ethanol extract of E. bulbosa bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy.

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Sari, R. A., Luthfiana, F., Sholihah, I., Matsunami, K., Sukardiman, S., & Widyowati, R. (2023). Antiosteoarthritis activities of 70% ethanol extract of <em>Eleutherine bulbosa</em> (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis. Journal of Public Health in Africa, 14(s1).


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