The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats

Authors

  • Tristiana Munandar Erawati Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya
  • Noorma Rosita Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya
  • Intan Rachmania Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya

DOI:

https://doi.org/10.4081/jphia.2023.2519

Keywords:

Candlenut oil, AMS oil, Nanostructured lipid carrier (NLC), Hair growth

Abstract

Background: Candlenut oil (Aleurites moluccana L. Willd), which is also called Aleurites moluccana Seed (AMS) oil, is empirically effective as a hair growth agent, it is an unstable substance. Nanostructured Lipid Carrier (NLC) is a delivery system that is proven to increase the effectiveness and stability of the material, and the usage of solid lipid combination: beeswax-oleum cacao can produce good NLC characteristics.

Objective: To determine the effectiveness of NLC_AMS oil with different combination of beeswax-oleum cacao (100:0; 50:50; 25:75; and 0:100) as a hair growth agent, using rats as subjects.

Methods: NLC-AMS oil was made using 20% of total lipid with 5% AMS oil as liquid lipid and 15% solid lipid; combinations of beeswax-oleum cacao were of different ratios (100:0; 50:50; 25:75; and 0:100). NLC was made by High Shear Homogenization (HPH) method. Hair growth activity test carried out on male white rats using the research methods of Yoon (2010).

Results: The addition of oleum cacao as a solid lipid did not affect the pH, but increased the consistency and decreased the particle size of NLC- AMS oil. There was a relationship between the characteristic of NLC and the hair growth activity test: the small particle size and low viscosity had greater hair growth activity.

Conclusion: The usage of solid lipid combination: beeswax-oleum cacao can produce better NLC characteristics and had higher hair growth activity than the formulas that used single lipid.

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Published

16-03-2023

How to Cite

Erawati, T. M., Rosita, N., & Rachmania, I. (2023). The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats. Journal of Public Health in Africa, 14(s1). https://doi.org/10.4081/jphia.2023.2519