@article{Sari_Luthfiana_Sholihah_Matsunami_Sukardiman_Widyowati_2023, title={Antiosteoarthritis activities of 70% ethanol extract of <em>Eleutherine bulbosa</em> (mill.) urb. bulb on rats monosodium iodoacetate-induced osteoarthritis}, volume={14}, url={https://www.publichealthinafrica.org/jphia/article/view/2506}, DOI={10.4081/jphia.2023.2506}, abstractNote={&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;: Osteoarthritis (OA) is a common degenerative joint situation that induces pain and disability in the elderly. Traditionally, &lt;em&gt;Eleutherine bulbosa&lt;/em&gt; bulb from Pasuruan, East Java, is used to treat many diseases, also as an anti-inflammatory.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Objective&lt;/strong&gt;: In this research, we employed an &lt;em&gt;in vivo&lt;/em&gt; model to examine the effects of 70% ethanol extracts of &lt;em&gt;E. bulbosa&lt;/em&gt; (EBE) on the progression and development of OA.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Methods&lt;/strong&gt;: A singular intraarticular injection of Monosodium Iodoacetate (MIA) was used to create the OA model in rats. The progression of OA was observed for three weeks. Furthermore, treatment of EBE at a dose of 6, 12, and 24 mg/200g BW orally for four weeks was conducted to assess the effects on decreasing IL- 1ß level, joint swelling, and hyperalgesia.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Results&lt;/strong&gt;: Induction was successful, indicated by a significant difference (P&amp;lt;0.05) in decreasing latency time, increasing joint swelling, and IL-1ß level. EBE 24 mg/200 g BW treatment has significantly (P&amp;lt;0.05) reduced IL-1ß levels, joint swelling, and response to hyperalgesia.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Conclusion&lt;/strong&gt;: The 70% ethanol extract of &lt;em&gt;E. bulbosa&lt;/em&gt; bulb has therapeutic effects on inflammation through reducing IL-1ß in experimental MIA-induced osteoarthritis in a rat model. According to this study, EBE may have an effective potential new agent for OA therapy.&lt;/p&gt;}, number={s1}, journal={Journal of Public Health in Africa}, author={Sari, Riza Ambar and Luthfiana, Fina and Sholihah, Irawati and Matsunami, Katsuyoshi and Sukardiman, Sukardiman and Widyowati, Retno}, year={2023}, month={Mar.} }