@article{Sulistyowaty_Putra_Ekowati_Widiandani_Matsunami_2023, title={<em>In silico</em> study of phytochemicals contained in <em>Brucea javanica</em> in inhibiting the InhA enzyme as antituberculosis}, volume={14}, url={https://www.publichealthinafrica.org/jphia/article/view/2518}, DOI={10.4081/jphia.2023.2518}, abstractNote={&lt;p&gt;&lt;strong&gt;Background&lt;/strong&gt;: Currently &lt;em&gt;Mycobacterium tuberculosis&lt;/em&gt; is found to be resistant to the treatment of tuberculosis with rifampin and isoniazid (INH) and often stated as multi-drug resistance (MDR). Knowledge and determination of biological properties of plant extracts is a source of drug candidates in various health fields. Therefore, natural products are important in the discovery of new drugs, especially in disease therapy, particularly for tropical dis- eases, tuberculosis. &lt;em&gt;Brucea javanica&lt;/em&gt;, known as &lt;em&gt;Buah Makasar&lt;/em&gt;, is found in many Asian countries including Indonesia. This plant fruit has a very bitter taste so it cannot be directly consumed and is often used as a traditional medicine to prevent some diseases, especially malaria. There has been no research on the effectiveness of &lt;em&gt;Buah Makasar&lt;/em&gt; in tuberculosis.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Objective&lt;/strong&gt;: This study aims to identify compounds contained in &lt;em&gt;Brucea javanica&lt;/em&gt;, namely &lt;em&gt;bruceines&lt;/em&gt;, &lt;em&gt;bruceosides&lt;/em&gt; and &lt;em&gt;yadanzio-sides&lt;/em&gt; in inhibiting the InhA enzyme found in the wall of Mycobacterium tuberculosis.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Methods&lt;/strong&gt;: This &lt;em&gt;in-silico&lt;/em&gt; study is using Molegro Virtual Docker (MVD) Ver. 5.5. We compared it to the native ligand, namely N-(4- Methylbenzoyl)-4-Benzylpiperidine (code: 4PI) and the reference drug standard, INH.&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Results&lt;/strong&gt;: In-silico results show that yadanziosides found in &lt;em&gt;Brucea javanica&lt;/em&gt; have the potential to inhibit the InhA enzyme. Bruceoside F (-190.76 Kcal/mol) has the lowest MolDock score among the 27 other compounds. It is also having lower MolDock score than the native ligand 4PI (-120.61 Kcal/mol) and INH (- 54.44 Kcal/mol).&lt;/p&gt; &lt;p&gt;&lt;strong&gt;Conclusions&lt;/strong&gt;: Brucea javanica can be considered as source of drug development for againts tuberculosis.&lt;/p&gt;}, number={s1}, journal={Journal of Public Health in Africa}, author={Sulistyowaty, Melanny Ika and Putra, Galih Satrio and Ekowati, Juni and Widiandani, Tri and Matsunami, Katsuyoshi}, year={2023}, month={Mar.} }