TY - JOUR AU - Erawati, Tristiana Munandar AU - Rosita, Noorma AU - Rachmania, Intan PY - 2023/03/16 Y2 - 2024/03/29 TI - The activity of candlenut oil in the nanostructured lipid carrier system on hair growth in rats JF - Journal of Public Health in Africa JA - J Public Health Afr VL - 14 IS - s1 SE - Original Articles DO - 10.4081/jphia.2023.2519 UR - https://www.publichealthinafrica.org/jphia/article/view/2519 SP - AB - <p><strong>Background</strong>: Candlenut oil (<em>Aleurites moluccana</em> L. Willd), which is also called Aleurites moluccana Seed (AMS) oil, is empirically effective as a hair growth agent, it is an unstable substance. Nanostructured Lipid Carrier (NLC) is a delivery system that is proven to increase the effectiveness and stability of the material, and the usage of solid lipid combination: beeswax-oleum cacao can produce good NLC characteristics.</p><p><strong>Objective</strong>: To determine the effectiveness of NLC_AMS oil with different combination of beeswax-oleum cacao (100:0; 50:50; 25:75; and 0:100) as a hair growth agent, using rats as subjects.</p><p><strong>Methods</strong>: NLC-AMS oil was made using 20% of total lipid with 5% AMS oil as liquid lipid and 15% solid lipid; combinations of beeswax-oleum cacao were of different ratios (100:0; 50:50; 25:75; and 0:100). NLC was made by High Shear Homogenization (HPH) method. Hair growth activity test carried out on male white rats using the research methods of Yoon (2010).</p><p><strong>Results</strong>: The addition of oleum cacao as a solid lipid did not affect the pH, but increased the consistency and decreased the particle size of NLC- AMS oil. There was a relationship between the characteristic of NLC and the hair growth activity test: the small particle size and low viscosity had greater hair growth activity.</p><p><strong>Conclusion</strong>: The usage of solid lipid combination: beeswax-oleum cacao can produce better NLC characteristics and had higher hair growth activity than the formulas that used single lipid.</p> ER -